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Tempus AI Short Interest Hits Record 25.7% as Shares Slide 19%

Tempus AI Stock Faces Increased Short Interest as Cathie Wood’s Ark Invest Sells, While Retail Traders Debate Rally’s Future

  • Short interest in Tempus AI reached a record 25.7% last week.
  • The stock declined 19% from its September high despite a raised price target.
  • Tempus AI acquired digital pathology firm Paige for $81.25 million.
  • The company secured FDA clearance and a $60.57 million research contract.
  • Major investors, including Ark Invest, reduced holdings while retail sentiment stayed neutral.

Short sellers increased their activity against Tempus AI last week, with short interest rising to an all-time high of 25.7%. This comes as the company’s share price dropped by 19% from its September peak.

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According to Ortex data, Tempus AI shares fell 11% over the past week. The record short interest reflects heightened bearish sentiment, even though Guggenheim raised its price target on the stock to $95, up from $80, and maintained a ‘Buy’ rating.

Recent company highlights included the acquisition of Paige, a digital pathology company, for $81.25 million. The purchase is expected to boost Tempus AI’s efforts in building a large oncology foundation model by adding roughly 7 million digitized pathology slides to its platform, which aids its Artificial Intelligence-driven cancer diagnostic tools.

The company also announced regulatory milestones and government partnerships. It received FDA clearance for its Tempus xR RNA-based diagnostic device and secured a $60.57 million contract from the U.S. Department of Health and Human Services. These developments aim to strengthen Tempus AI’s research and diagnostic capabilities.

Despite these advancements, some major stakeholders have reduced their positions. Ark Invest’s ARK Innovation ETF has sold over $10 million worth of Tempus AI shares in recent weeks. Discussing the stock’s technical outlook, some retail traders described current trading as “choppy” and highlighted $90 as a key resistance level, while others argued that recent negative sentiment could be exaggerated.

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Tempus AI stock remains up more than 100% so far in 2025.

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